Translational approaches utilized in our laboratory
Integration of whole blood DNA methylation profiles with host gene-expression signatures to identify subclass-specific mechanistic drivers of pathobiology of pediatric septic shock.
Isolation of PBMCs to develop patient-specific induced pluripotent stem cells (iPSCs) from critically ill children with septic shock for mechanistic research.
Translational approaches to study organ-specific microvascular endothelial responses in pediatric critical illness using circulating endothelial cell transcriptomic and iPSC derived organoids.