Peer-reviewed publications:

2024

Atreya MR, Huang M, Moore AR, Zheng H, Hasin-Brumshtein Y, Fitzgerald JC, Weiss SL, Cvijanovich NZ, Bigham MT, Jain PN, Schwarz AJ, Lutfi R, Nowak J, Thomas NJ, Quasney M, Dahmer MK, Baines T, Haileselassie B, Lautz AJ, Stanski NL, Standage SW, Kaplan JM, Zingarelli B, Sahay R, Zhang B, Sweeney TE, Khatri P, Sanchez-Pinto LN, Kamaleswaran R. Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes. Crit Care. 2024 Jul 17;28(1):246. doi: 10.1186/s13054-024-05020-z. PMID: 39014377. https://ccforum.biomedcentral.com/articles/10.1186/s13054-024-05020-z

Stevens J, Tezel O, Bonnefil V, Hapstack M, Atreya MR. Biological basis of critical illness subclasses: from the bedside to the bench and back again. Crit Care. 2024 May 29;28(1):186. doi: 10.1186/s13054-024-04959-3. PMID: 38812006; PMCID: PMC11137966. https://ccforum.biomedcentral.com/articles/10.1186/s13054-024-04959-3

Atreya MR, Bennett TD, Geva A, Faustino EVS, Rogerson CM, Lutfi R, Cvijanovich NZ, Bigham MT, Nowak J, Schwarz AJ, Baines T, Haileselassie B, Thomas NJ, Luo Y, Sanchez-Pinto LN; Novel Data-Driven Sepsis Phenotypes in Children Study and the Genomics of Pediatric Septic Shock Investigators. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatr Crit Care Med. 2024 Mar 11. doi: 10.1097/PCC.0000000000003499. Epub ahead of print. PMID: 38465952.

Atreya MR, Cvijanovich NZ, Fitzgerald JC, Weiss SL, Bigham MT, Jain PN, Abulebda K, Lutfi R, Nowak J, Thomas NJ, Baines T, Quasney M, Haileselassie B, Sahay R, Zhang B, Alder MN, Stanski NL, Goldstein SL. Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study. Crit Care Explor. 2024 Jan 16;6(1):e1027. doi: 10.1097/CCE.0000000000001027. PMID: 38234587; PMCID: PMC10793970.

2023:

Atreya MR, Banerjee S, Lautz AJ, Alder MN, Varisco BM, Wong HR, Muszynski JA, Hall MW, Sanchez-Pinto LN, Kamaleswaran R; Genomics of Pediatric Septic Shock Investigators. Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness. EBioMedicine. 2023 Dec 23;99:104938. doi: 10.1016/j.ebiom.2023.104938. Epub ahead of print. PMID: 38142638. DOI: 10.1016/j.ebiom.2023.104938

Stanski NL, Basu RK, Cvijanovich NZ, Fitzgerald JC, Bigham MT, Jain PN, Schwarz AJ, Lutfi R, Thomas NJ, Baines T, Haileselassie B, Weiss SL, Atreya MR, Lautz AJ, Zingarelli B, Standage SW, Kaplan J, Chawla LS, Goldstein SL. External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock. Crit Care. 2023 Nov 28;27(1):463. doi: 10.1186/s13054-023-04746-6. PMID: 38017578; PMCID: PMC10683237.

Atreya MR, Piraino G, Cvijanovich NZ, Fitzgerald JC, Weiss SL, Bigham MT, Jain PN, Schwarz AJ, Lutfi R, Nowak J, Thomas NJ, Baines T, Haileselassie B, Zingarelli B. Serum Humanin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome. Shock. 2023 Nov 1. doi: 10.1097/SHK.0000000000002266. Epub ahead of print. PMID: 37917869.

Wösten-van Asperen RM, la Roi-Teeuw HM, van Amstel RB, Bos LD, Tissing WJ, Jordan I, Dohna-Schwake C, Bottari G, Pappachan J, Crazzolara R, Comoretto RI, Mizia-Malarz A, Moscatelli A, Sánchez-Martín M, Willems J, Rogerson CM, Bennett TD, Luo Y, Atreya MR, Faustino EVS, Geva A, Weiss SL, Schlapbach LJ, Sanchez-Pinto LN; POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric & Neonatal Intensive Care), and; Novel Data-Driven Sepsis Phenotypes in Children study group. Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes-an international multicentre retrospective study. EClinicalMedicine. 2023 Oct 5;65:102252. doi: 10.1016/j.eclinm.2023.102252. PMID: 37842550; PMCID: PMC10570699.

Huang M, Atreya MR, Holder A, Kamaleswaran R. A MACHINE LEARNING MODEL DERIVED FROM ANALYSIS OF TIME-COURSE GENE-EXPRESSION DATASETS REVEALS TEMPORALLY STABLE GENE MARKERS PREDICTIVE OF SEPSIS MORTALITY. Shock. 2023 Nov 1;60(5):671-677. doi: 10.1097/SHK.0000000000002226. Epub 2023 Sep 23. PMID: 37752077.

Atreya MR, Cvijanovich NZ, Fitzgerald JC, Weiss SL, Bigham MT, Jain PN, Schwarz AJ, Lutfi R, Nowak J, Thomas NJ, Quasney M, Haileselassie B, Baines TD, Zingarelli B; Genomics of Pediatric Septic Shock Investigators. SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME. Shock. 2023 Sep 1;60(3):379-384. doi: 10.1097/SHK.0000000000002183. Epub 2023 Jul 25. PMID: 37493567; PMCID: PMC10529838.

Atreya, MR, Cvijanovich, N.Z., Fitzgerald, J.C. et al. Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock. Crit Care 27, 260 (2023). https://doi.org/10.1186/s13054-023-04554-y

Atreya, MR., Cvijanovich, N.Z., Fitzgerald, J.C. et al. Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1. Crit Care 27, 250 (2023). https://doi.org/10.1186/s13054-023-04535-1

Sanchez-Pinto LN, Bennet TD, Stroup EK, Luo Y, Atreya MR, Bubeck Wardenburg J, Chong G, Geva A, Faustino EVS, Farris RW, Hall MW, Rogerson C, Shah SS, Weiss SL, Khemani RG. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock. Pediatr Crit Care Med. 2023 Jun 2. https://doi.org/10.1097/pcc.0000000000003292

Benscoter, A.L., Alten, J.A., Atreya, MR. et al. Biomarker-based risk model to predict persistent multiple organ dysfunctions after congenital heart surgery: a prospective observational cohort study. Crit Care 27, 193 (2023). https://doi.org/10.1186/s13054-023-04494-7

Sanchez-Pinto LN, Bhavani SV, Atreya MR & Sinha P. Leveraging Data Science and Novel Technologies to Develop and Implement Precision Medicine Strategies in Critical Care. Critical Care Clinics (2023). [https://doi.org/10.1016/j.ccc.2023.03.002]

Atreya MR, Sanchez-Pinto LN, Kamaleswaran R. Commentary: 'Critical illness subclasses: all roads lead to Rome'. Crit Care. 2022 Dec 14;26(1):387. doi: 10.1186/s13054-022-04265-w. PMID: 36517867; PMCID: PMC9749358. https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04265-w

Atreya MR, Cvijanovich NZ, Fitzgerald JC, Weiss SL, Bigham MT, Jain PN, Schwarz AJ, Lutfi R, Nowak J, Allen GL, Thomas NJ, Grunwell JR, Baines T, Quasney M, Haileselassie B, Lindsell CJ, Alder MN, Wong HR. Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study. Crit Care. 2022 Jul 11;26(1):210. doi: 10.1186/s13054-022-04070-5. PMID: 35818064; PMCID: PMC9275255. https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04070-5

2022

Prior to 2022

Atreya MR, Whitacre BE, Cvijanovich NZ, Bigham MT, Thomas NJ, Schwarz AJ, Weiss SL, Fitzgerald JC, Allen GL, Lutfi R, Nowak JE, Quasney MW, Shah AS, Wong HR. Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock. Crit Care Med. 2020 Oct;48(10):1513-1520. doi: 10.1097/CCM.0000000000004487. PMID: 32769621; PMCID: PMC8477606. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477606/

Atreya MR, Wong HR. Precision medicine in pediatric sepsis. Curr Opin Pediatr. 2019 Jun;31(3):322-327. doi: 10.1097/MOP.0000000000000753. PMID: 31090572; PMCID: PMC6530487. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530487/